Phenome-wide mr
Web14. okt 2024 · A phenome-wide analysis of our MR–PRS, constructed from SNPs associated with the identified risk factors for Alzheimer’s disease, indicated shared genetic … Web29. dec 2024 · Phenome-wide Mendelian randomization of BMI and outcomes We conducted MR analysis of the 1244 phecodes in up to 174,915 EA participants. Of the phecodes associated with standardized …
Phenome-wide mr
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Web23. feb 2024 · Phenome-wide association studies: a new method for functional genomics in humans Dan M. Roden, Corresponding Author Dan M. Roden [email protected] orcid.org/0000-0002-6302-0389 Departments of Medicine, Pharmacology and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA In the initial MR analysis, proteins were treated as the exposures and 225 complex human phenotypes as the outcomes (Fig. 1; estimate putative causal relationship). Due to high correlation among some of the tested phenotypes (for example, coronary heart disease and myocardial infarction), we used the … Zobraziť viac pQTLs from five GWAS9,13,14,15,16 were used for the instrument selection (Fig. 1). We first mapped SNPs to genome build GRCh37.p13 coordinates and then … Zobraziť viac We further classified the 2,113 instruments into three groups (noted as tier 1, 2 and 3 instruments) using two major instrument-filtering steps: a specificity … Zobraziť viac Absence of horizontal pleiotropy is one of the core assumptions for MR. This assumes that the genetic variant should only be related to the outcome of interest … Zobraziť viac Among the 2,113 pQTLs selected as instruments, we looked up available protein GWAS results (Sun et al.9, Suhre et al.13 and Folkersen et al.14 with full … Zobraziť viac
Web23. nov 2024 · We performed phenome-wide Mendelian randomization analysis (MR-PheWAS), two-sample MR analysis, and systemic review to comprehensively explore the … WebMR analyses were performed to assess the associations of blood metabolites with AD, and a phenome-wide MR analysis was further applied to ascertain the potential on-target side effects of metabolite interventions. ... Phenome-wide MR analysis showed that epiandrosterone sulfate, 5alpha-androstan-3beta-17beta-diol disulfate and sphingomyelin ...
Web6. júl 2024 · Proteome-by-phenome MR, in common with all other MR studies, has three key assumptions that must be fulfilled to ensure the legitimacy of any ... Zheng J, Haberland V, Baird D, Walker V, Haycock P, Gutteridge A, et al. Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases. bioRxiv. 2024 [cited … Web15. mar 2024 · MR analysis from phenome-wide traits to atrial fibrillation MR analyses suggested that out of 5048 exposures (3046 non-protein measures and 2002 proteins), 55 …
Web12. apr 2024 · Methods: A phenome-wide Mendelian randomization (MR) study of anti-VZV immunoglobulin G (IgG) levels with 1370 traits was conducted to explore the potential causal role of VZV-specific immune response on multiple traits using the UK Biobank cohort. For the robustness of the results, we performed MR analyses using five different methods.
Web5. feb 2024 · Here we conducted a phenome-wide Mendelian randomisation (MR-PheWAS) analysis and a systematic review for MR studies to comprehensively investigate the health effects of serum calcium. Methods. One-hundred and thirty genetic variants strongly associated with serum calcium levels were used as instrumental variables. A phenome … couch cleaning oakdenWeb7. sep 2024 · Our phenome-wide MR study of the plasma proteome employed fivepQTL studies to robustly identify and validate genetic instruments for thousands of proteins. We … bredemeijer cosy manto theepotWeb23. nov 2024 · Background We performed phenome-wide Mendelian randomization analysis (MR-PheWAS), two-sample MR analysis, and systemic review to comprehensively explore the health effects of milk consumption in the European population. Methods Rs4988235 located upstream of the LCT gene was used as the instrumental variable for milk … couch cleaning ormeau hillsWeb26. feb 2024 · Phenome-wide Mendelian randomization (MR) analysis has been proposed as a hypothesis-searching approach to comprehensively examine causality between … couch cleaning ormistonWeb27. júl 2024 · The development of MR–phenome-wide association study (MR-PheWAS) has been proven to be helpful in these above scenarios and has been used for other important risk factors such as vitamin D , serum urate levels , and coffee consumption . The release of large “Biobank” datasets provides a unique opportunity and could include phenotypes that ... bredemus hardware coWeb13. sep 2024 · We then implemented a Mendelian Randomization–Phenome Wide Association Study (MR-PheWAS) analysis on data from 339 256 individuals of White British origin from UK Biobank. We first ran a PheWAS analysis to test the associations between a 25(OH)D polygenic risk score and 920 disease outcomes, and then nine phenotypes (i.e. … couch cleaning obi obiWebRecent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here we estimated the … brede mobility cars east sussex