High affinity copper uptake protein 1-like

WebHuman CTR1 is a high-affinity copper transporter that also mediates the uptake of the anticancer drug cisplatin by largely unknown transport mechanisms. Here we report the 6 … WebHigh affinity copper uptake protein 1 Alternative names Copper transporter 1 ( rCTR1) Liver regeneration-related protein LRRGT00200 Solute carrier family 31 member 1 …

Copper signalling: causes and consequences - PMC

WebIt has been claimed that human copper transporter 1 (hCTR1), the human high-affinity copper transporter, is the major entry pathway for cDDP and related drugs via a mechanism that mimics copper. This is an unexpected property of … WebThe affinity measured by Km value for the drugs transported by their corresponding DTs were unified to the unit of micromolar 4. 2D and 3D Structures of Small Molecular Drugs The structures of the small molecular drugs transported by DTs were drawn and were standardized in the .sdf format (both 2D and 3D) 5. flood marine whaly boats https://thev-meds.com

The copper transporter CTR1 and cisplatin accumulation at the …

Web10 de abr. de 2024 · Abstract Heavy metal contamination impacts plant growth and productivity by causing damage at all levels of plant organization, making it one of the most significant abiotic stressors. This study evaluated the uptake and distribution of cadmium (Cd) and copper (Cu) in Solanum lycopersicum L. and identified the antioxidant enzyme … Web15 de abr. de 2024 · High affinity copper uptake protein 1 (pig) Protein Target - PubChem Apologies, we are having some trouble retrieving data from our servers... WebHigh affinity copper uptake protein 1: Synonyms: Copper transporter 1; Solute carrier family 31 member 1; hCTR1; Gene Name: SLC31A1: Protein Type: Transporter: … great minds job reviews

SOLUTE CARRIER FAMILY 31 (COPPER TRANSPORTER), MEMBER 1; SLC31A1

Category:Dynamical interplay between the human high-affinity copper …

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High affinity copper uptake protein 1-like

RCSB PDB - 6M97: Crystal structure of the high-affinity copper ...

WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at … Webencode a high affinity copper uptake process and was found to be 29% identical at the primary structure level with Ctr1 from yeast. The human protein was, however, substantially smaller than the yeast protein, being composed of 190 amino acids as compared with 406 amino acids (see Fig. 1). hCTR1 is on the

High affinity copper uptake protein 1-like

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WebCopper uptake transmembrane transporter activity Specific Function High-affinity, saturable copper transporter involved in dietary copper uptake. Pfam Domain Function. … Web27 de mar. de 2024 · The high-affinity Cu transporter Ctr1 ( Km ≈ 2 μM) 4, an integral membrane protein localized to the plasma membrane and endosomal vesicles, mediates cellular Cu uptake in eukaryotes from...

WebThese high-affinity copper transporters exist in all eukaryotes and their discovery has provided new insights into how cells acquire and regulate this essential nutrient. The … WebCopper is an essential cofactor for key processes in plants, but it exerts harmful effects when in excess. Previous work has shown that the Arabidopsis (Arabidopsis thaliana) COPT1 high-affinity copper transport protein participates in …

WebGene ID: 100178573, updated on 26-Oct-2024. Summary Other designations. high affinity copper uptake protein 1-like Web25 de set. de 2024 · Abstract Copper is crucial for carrying out normal physiological functions in all higher life forms. Copper Transporter 1 (CTR1) is the high-affinity copper importer found in all eukaryotic organisms. The copper transporter family primarily comprises ~ six members (CTR1-6) and the related members share high sequence …

Web17 de nov. de 2024 · The expression of the high affinity Cu uptake system is transcriptionally regulated by a copper metalloregulatory transcription factor (CuMRTF) named ScMac1 ( Labbe et al., 1997; Keller et al., 2005 ). In the absence of copper, ScMac1 is able to bind DNA, thereby activating the expression of the high affinity Cu uptake …

Web16 de mar. de 2010 · Copper and iron are essential elements employed in pathways that are conserved in all kingdoms of life. In eukaryotes, several interdependent connections between copper and iron homeostasis have been described previously ().For example, high-affinity iron uptake in Saccharomyces cerevisiae is mediated by multicopper … great minds in stem gmis conferenceWeb5 de abr. de 2024 · Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion Epub 2024 Feb 22. Authors Gulshan Walke 1 … flood marine northern irelandWebGene ID: 102804936, updated on 5-Feb-2024. Summary Other designations. high affinity copper uptake protein 1-like flood marr hockey tournamentWebProtein target information for High affinity copper uptake protein 1 (house mouse). Find diseases associated with this biological target and compounds tested against it in … great minds in stem conference 2023http://varidt.idrblab.net/ great minds in the worldWebBecause copper uptake at the cell membrane is a crucial step in copper acquisition, yeast genes encoding the high affinity copper transport proteins are tightly regulated in response to copper levels to ensure … great minds international schoolWeb1 de jan. de 2024 · This high-affinity copper transporter takes up Cu + from the intestinal lumen to the epithelial cell, in an energy-independent manner [2], [3]. CTR1 is the major copper importer present on the apical site of enterocytes, but conflicting reports have also shown a possible role of DMT1 in copper transfer into intestinal cells. great minds math login