Cytofectins
WebSep 17, 1996 · Amine containing compounds and their use in the generation of cytofectin:polynucleotide complexes for transfection of cells, formulations, counterions, and reaction conditions for maximizing the transfection include using cationic amine compounds that have the general structure: ##STR1## wherein R.sub.4 and R.sub.5 are a pair of …
Cytofectins
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WebSep 28, 2008 · Finally, the compounds have been introduced into man in a gene therapy clinical trial recently initiated by Nabel etal. Because there is now a rapidly growing list of compounds that act by a similar mechanism we are referring to this class of polynucleotide delivery reagents as the “Cytofectins”. WebFeb 15, 2002 · Anchor-dependent lipofection with non-glycerol based cytofectins containing single 2-hydroxyethyl head groups Detailed structure-activity investigations aimed at probing the anchor chain length dependency for glycerol-based lipofectins have been reported previously.
WebMar 9, 2011 · Cytotoxins. Cytotoxins are the chemical weapons that Killer T-cells use to destroy infected cells. Viruses take over healthy cells and trick them into making many … Webproduce cytofectins which afford liposomes with high transfection potential, the nature of the linkage, spacer length and cationic head group have been examined (Figure 1). Thus, it has been shown that the ether linkage between the hydrophobic cholesteryl skeleton and the spacer affords compounds which lead to higher transfection ...
WebThis invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this inventio WebSep 28, 2008 · Download Citation Cationic Lipid/Polynucleotide Condensates for in Vitro and in Vivo Polynucleotide Delivery - the Cytofectins Abstract Cationic liposomes have …
WebApr 4, 2002 · Both of these cytofectins are predicted to produce relatively fluid bilayer liposome structures due to the short alkyl side chain of GAP-DLRIE (C12:0) and the mono-unsaturated C14 side chain of GAP-DMORIE (C14:1). In addition, the co-lipid used in the lipoplex formulations is also important, and thus structural differences in either or both ...
WebNov 1, 2005 · Novel N,N‘-diacyl-1,2-diaminopropyl-3-carbamoyl[bis-(2-dimethylaminoethane)] bivalent cationic lipids were synthesized and evaluated for in … song atlantic city lyricsWebSep 28, 2008 · Cationic amphiphiles (cytofectins) are widely used for the transfection of cultured cells, and may become useful for the development of genetic medicines. … song at last by the velvetsWebFeb 5, 1999 · The most promising advances in nonviral gene transfer have been in the production of synthetic cationic liposomes formulated with cationic lipids (cytofectins) able to transfect cells. Such... song atlantic city by bruce springsteenWebA large number of liposome-based non-viral gene and siRNA delivery systems include monovalent cholesteryl cytofectins with acyclic head groups in their formulations. Progress in their clinical development has, however, been hampered by relatively low transfection efficiencies. Structural differences between members of this class of cationic amphiphiles … song atlantic city you tubeWebPromising advances in nonviral gene transfer have been made as a result of the production of cationic liposomes formulated with synthetic cationic lipids (cytofectins) that are able to transfect cells. However few cationic liposome systems have been examined for their ability to transfect CNS cells. song atlantis lyricsWebProvided is a collection of cytofectins (cytofectins are defined as chemical species that are cationic transfection amphiphiles) or cationic lipids that bind and transport … song atlanta rhythm sectionWebJun 28, 2015 · A large number of liposome-based non-viral gene and siRNA delivery systems include monovalent cholesteryl cytofectins with acyclic head groups in their formulations. Progress in their clinical... song at night i think of you