Cisplatin solubility in pbs
WebJan 1, 2013 · Cisplatin is a weakly acidic drug with a pKa from 5.5 to 7.3 in its monohydrated and dihydrated complex form [46]. Cisplatin solubility in DI water is 2.5 mg/mL (at 25 °C), which increases up... WebFeb 3, 2024 · The solubility of cisplatin in different lipids was assessed with slight alterations according to previously reported techniques ... Japan) at 307 nm was used to determine the efficacy of encapsulation. In the phosphate-buffered solution (PBS, 0.01 M, pH 7.4), lyophilized nanoparticles were dissolved. It was sonicated for 20 min, and then ...
Cisplatin solubility in pbs
Did you know?
WebSep 30, 2024 · Introduction. Cisplatin (cis-diamminedichloridoplatinum(II), CDDP) is one of the most commonly used antineoplastic drugs worldwide. The platinum-based compound has been in clinical use for more than 40 years and is a cost-effective first-in-line treatment against several solid cancers including ovarian, head and neck and testicular cancer … WebCisplatin (4) Cisplatin Synonyms: cis-Diammineplatinum (II) dichloride, cis-Dichlorodiammine platinum (II), cis-Platinum (II) diammine dichloride, Cisplatin Linear Formula: Pt (NH3)2Cl2 CAS Number: 15663-27-1 Molecular Weight: 300.05 EC Number: 239-733-8 Product Comparison Guide Use the product attributes below to configure the …
WebCisplatin is soluble in organic solvents such as DMSO* and dimethyl formamide (DMF), which should be purged with an inert gas. It is also soluble in water. The solubility of … WebFeb 24, 2024 · The slow release of biasplatin and biasplatin@MIL-101 (Fe) was conducted in PBS solution pH 7.20, 37 °C as media and measured by UV–Vis spectrophotometer. The release of biasplatin without loaded into MIL-101 (Fe) is persistent for 3%, and biasplatin@MIL-101 (Fe) is 0.05% over 72 h.
WebMay 7, 2024 · Cisplatin is poorly water-soluble, with marginal solubility (approximately 0.15 wt% 16 ). The 50 wt% TMG aq. dissolved 1.7 wt% of cisplatin (Table 1 ). The diluted TMG solutions (25 and 5... WebCisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Synonym …
WebCisplatin CATALOG NUMBER: JM-1550-1000 AMOUNT: 1 g MOLECULAR FORMULA: Pt(NH3)2Cl2 MOLECULAR WEIGHT: 300.0 PURITY: >98% by HPLC APPEARANCE: Yellow solid SOLUBILITY: Soluble in DMSO (10 mg/ml); dimethylformamide (24 mg/ml); water or saline (1mg/ml) at 19oC. In aqueous solutions, cisplatin slowly changes to the …
Webcis-Diamineplatinum(II) dichloride ≥99.9% trace metals basis All Photos(2) Synonym(s): cis-Diammineplatinum(II) dichloride, cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin Linear Formula: Pt(NH3)2Cl2 CAS Number: 15663-27-1 Molecular Weight: 300.05 EC Number: 239-733-8 MDL number: MFCD00011623 cry 意味はWebJan 7, 2024 · Cancer is known to be one of the major causes of death nowadays. Among others, chemotherapy with cisplatin is a commonly used treatment. Although widely employed, cisplatin is known to cause severe side effects, such as nerve and kidney damage, nausea, vomiting, and bone marrow suppression. Most importantly, a number … dynamics st albertWebJan 1, 1979 · The stability of cisplatin (cis-diamminedichloroplatinum) in aqueous solution at pH 4 was investigated; a modified ultraviolet spectroscopy assay method for cisplatin was developed. ... Solubility at 4 ± 2 C was tested by diluting the drug with 0.9% sodium chloride injection to 0.4, 0.5, 0.6, 0.7,6.8 and 0.9 mg/ml. ... dynamics statecodeWebcis-Diamminedichloroplatinum Cisplatinum NSC 119875 Molecular Formula Cl2H6N2Pt Formula Weight 300.1 Purity ≥95% Formulation(Request formulation change) A crystalline solid Solubility(Learn about Variance in Solubility) DMF: 10 mg/ml DMSO: 20 mg/ml** PBS (pH 7.2): 1 mg/ml (with warming) Water: 1 mg/ml (with warming) SMILES cry行为WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … dynamics steelWebCisplatin Cl2H6N2Pt - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 503 National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health crz 07 facebookWebMay 5, 2024 · Cisplatin was dissolved in PBS (1 mM), DMSO (1 M), H 2 O (1 mM) or DMF (1 mM) and heated for several hours to generate the stock solution at the concentration … dynamics ssis